Accession Number:

ADB134571

Title:

Interferon Inducers against Infectious Diseases

Descriptive Note:

Annual rept. 23 Mar 1988-22 Mar 1989

Corporate Author:

ROSWELL PARK MEMORIAL INST BUFFALO NY

Personal Author(s):

Report Date:

1989-04-01

Pagination or Media Count:

53.0

Abstract:

We have been able to formulate effective IFN inducers without CMC. Most of these inducers are less toxic than is ICLC, and some are about as toxic as IC itself. Therefore, the other components are essentially non-toxic. Preliminary data showed that one formulation may be less toxic than is IC. All but one of the formulations so far tested for immunogenicity have given negative results the one exception is to be examined further. We have a number of formulation which are effective IFN inducers, and some which are effective against Rift Valley Fever virus in mice. Some show both activities. Keywords RA1 Interferon Antiviral agents Poly ICLC Carboxymethyl saccharides.

Subject Categories:

  • Biochemistry
  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE