Accession Number:

ADB134375

Title:

Electrical Stimulation for Physiologic Measurement of Neuromuscular Function and Respiratory Support During Anticholinesterase

Descriptive Note:

Annual rept. Oct 1983-Sep 1984

Corporate Author:

TENNESSEE UNIV CENTER FOR THE HEALTH SCIENCES MEMPHIS

Personal Author(s):

Report Date:

1984-10-01

Pagination or Media Count:

23.0

Abstract:

The purpose of this research is to develop the techniques necessary for providing short-term respiratory support for personnel poisoned by organophosphate agents. Following acute exposure to organophosphate compounds, respiration ceases before cardiovascular collapse occurs. Military personnel exposed to these compounds in the field are most likely to die from asphyxiation. By virtue of their ability to cross the blood-brain barrier and inhibit cholinesterase activity the organophosphates are capable of interrupting control of respiration either centrally i.e. within the central nervous system or peripherally by blocking neuromuscular transmission or contraction coupling at the peripheral muscles. We hypothesize that it will be possible to overcome organophosphate induced respiratory arrest by providing artificial respiratory pacing. This research is aimed at producing a means of respiratory support via electronic stimulation of the phrenic nerve s that can be used when central respiratory drive has become blocked by organophosphate agents. Animal experiments have been conducted to implement and evaluate the transesophageal electrophrenic stimulation technique TEST for respiratory pacing and to determine appropriate stimulation parameters to produce effective and efficient respirations.

Subject Categories:

  • Medicine and Medical Research
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE