Mustard Contact Hazard, Correlation of Effects in Skin with Contamination Levels Recovered from Dental Dam and Painted Steel Surfaces. 1. Animal and Chemical Data
Technical rept. Feb-Nov 1985
CHEMICAL RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUND MD
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Testing was performed to determine if the degree of skin irritation in rabbits resulting from direct or vapor contact with mustard hd could be used to predict the amount of HD that had caused the injury. A series of tests were conducted to determine the degree of skin injury from known levels of HD contamination. In a second series of tests, skin injury was used to quantify the level of HD contamination. These results indicate that skin injury is related to the total amount of HD in contact with the skin, but only when the skin was contacted by a discrete droplet. If the HD contamination resulted from a source other than a discrete droplet i.e., residue in a painted surface, then the correlation between agent dose and skin irritation cannot be closely predicted. It was also determined that rabbit skin is much more sensitive to the insult of HD than swine skin. Rabbit skin was about five times more sensitive at the lower levels of contamination below 1.0 mg. Therefore, if a laboratory animal indicator of HD surface contamination is needed, the rabbit would be the species of choice.
- Chemical, Biological and Radiological Warfare