Accession Number:

ADB126086

Title:

Research in Drug Development against Viral Diseases of Military Importance (Biological Testing)

Descriptive Note:

Technical Report,15 Nov 1986,14 Nov 1987

Corporate Author:

SOUTHERN RESEARCH INST BIRMINGHAM AL BIRMINGHAM United States

Report Date:

1987-12-15

Pagination or Media Count:

394.0

Abstract:

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves a primary testing of chemical compounds and natural products for antiviral efficacy in vitro using CPE-inhibition and plaque-reduction assays, b primary testing of compounds for antiviral efficacy in vivo in animal model systems, and c secondary evaluation of the active candidate antiviral compounds. The target viruses for invitro testing are Vaccinia Virus VV, Adenovirus AD, Vesicular Stomatitis Virus VSV, Punta Toro Virus PT, Sandfly Fever Virus SF, Yellow Fever Virus YF, Venezuelan Equine Encephalomyelitis Virus VEE, Japanese Encephalitis Virus JE, Pichinde Virus PIC, Hantaan Virus HTN, Human Immunodeficiency Virus HIV, and related murine, feline, and simian retroviruses. The current in vivo systems are Pichinde Virus infection of hamsters and Venezuelan Equine Encephalomyelitis Virus infection of mice. During this second year of the project all in vitro and in vivo screening systems became operational. Antiviral drugs, RNA Viruses, AIDS. AWMJM

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE