Accession Number:

ADB123568

Title:

Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies

Descriptive Note:

Technical Report,01 Apr 1987,31 Mar 1988

Corporate Author:

SRI INTERNATIONAL MENLO PARK CA MENLO PARK United States

Report Date:

1988-04-01

Pagination or Media Count:

200.0

Abstract:

SRI International and Utah State University are developing methodology to assess the effectiveness of antiviral drug-monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pichinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates will be screened for antiviral activity both in vitro and in animal model systems. Keywords Binding sites, Antiviral agents, Monoclonal antibodies.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE