Interferon Inducers against Infectious Diseases
Technical Report,23 Mar 1987,22 Mar 1988
HEALTH RESEARCH INC BUFFALO NY BUFFALO United States
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The double-stranded synthetic polynucleotide poly I poly C i.e., poly-inosinic-poly-cyticylic acid, also to be called poly IC or IC is an interferon IFN inducer. In primates it is not effective, presumably because of circulating nucleases which quickly degrade it. When complexed with cationic polyL-lysine, PLL, and anionic carboxymethylcellulose, CMC, it is effective in humans. But CMC presents some difficulties it is not excreted or metabolized, and it is suspected as a carcinogen 1. The problem being addressed in this research is the preparation of effective, safe IFN inducers devoid of CMC. To this end our main efforts have been to develop anionic polymers to replace CMC. We are also seeking to replace CMC by modifying the PLL with engrafted polysaccharides. Since CMC has undesirable features, including non-excretion, non-metabolization, and possible carcinogenicity, we are seeking formulations without CMC. We are exploring two approaches to this goal. One is the replacement of CMC with other anionic biopolymers, selected on the basis of known or expected safety, and being excretable or metabolizable. Keywords SynthesisChemistry.