Testing of Experimental Compounds for Efficacy against Leishmania.
Annual rept. 1 Jan-31 Dec 87,
GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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A total of 309 new compounds of diverse chemical classes consisting of compounds with activity against other parasites, activity against viruses, or having chemical structures suggestive of being antimetabolites were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. Seven of these were active. In comparison to the activity of the reference compound, Glucantime, one-half of these had activity approximately equal to Glucantime while the activity of the others was less than that of the reference compound. Keywords Chemotherapy WR06026 Chemoprophylactic Antileishmanial agents. KT