Accession Number:

ADB122469

Title:

Study of Potential Prophylactic and Antidotal Use of Scavenging Agents in Treatment of Cyanide Poisoning

Descriptive Note:

Final rept. 1 Jan 1983-31 Aug 1984

Corporate Author:

MISSISSIPPI UNIV MEDICAL CENTER JACKSON DEPT OF PHARMACOLOGY AND TOXICOLOGY

Personal Author(s):

Report Date:

1984-11-15

Pagination or Media Count:

39.0

Abstract:

The purpose of this project was to investigate the effectiveness of pretreatment with potential cyanide antagonists in protecting against the lethal effects of cyanide. The primary methodology used was LD50 studies in mice. Some studies involving intravenous infusion were done using rats. The data indicate that alpha-ketoglutaric acid is the most potent single chemoprophylactic agent reported in the literature. When a combination of alpha-ketoglutaric acid and sodium thiosulfate was administered to animals prior to injection of cyanide, the LD50 increased 20 fold compared to that in animals given saline pretreatment. This combination of alpha-ketoglutaric acid and sodium thiosulfate produced a 2.9-fold greater increase in LD50 than did the classic combination of sodium nitrite and sodium thiosulfate. Keywords Chemotherapeutic agents Toxins and antitoxins.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE