Accession Number:

ADB122370

Title:

Effects of Methemoglobin Versus Potassium Cyanide Intoxication

Descriptive Note:

Final rept. 15 Mar 1983-31 Dec 1986

Corporate Author:

FOOD AND DRUG RESEARCH LABS INC WAVERLY NY

Personal Author(s):

Report Date:

1987-08-01

Pagination or Media Count:

81.0

Abstract:

Studies were conducted in Beagle dogs to evaluate the efficacy of selected compounds as to potential antidotes against cyanide intoxication in an attempt to develop a drug or regimen of drugs which can be used for protection against cyanide intoxication in a battlefield situation where the threat of cyanide exposure is a likely possibility. The majority of the research centered around measuring the degree of protection from lethal intravenous doses of potassium cyanide KCN achieved primarily by increasing blood methemoglobin levels. Initially, the acute LD50 of intravenously administered potassium cyanide was determined. In addition, the chemical method for determining methemoglobin in the blood of dogs was validated and the kinetics of methemoglobin formation and disappearance following administration of WR 6026, an 8-aminoquinoline experimental anti-leishmanial drug, was evaluated. Next, studies were conducted investigating the effect of pre-existing levels of methemoglobin induced by WR 6026 on the ability of the dog to resist cyanide intoxication. Protective indexes against KCN intoxication were established for 10-12 and 5-6 methemoglobin levels induced by WR 6026. The effect of increased blood methemoglobin levels and intravenous sodium thiosulfate vs. cyanide intoxication was validated. The kinetics of methemoglobinemia induced by intramuscular injection of hydroxylamine hydrochloride was investigated. AW

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE