Chemotherapy of Rodent Malaria. Part 1
Annual rept. 1 Jul 1986-30 Jun 1987
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE (UNITED KINGDOM)
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The main emphasis of work has been on our continuing studies into drug resistance, involving further examinations of cross-resistance patterns in resistant lines. In addition, ultrastructural studies comparing treated and untreated parasites resistant to a wide range of antimalarials have been carried out. Some preliminary studies into the in vivo effect of calcium channel blockers on chloroquine resistant strains of rodent malaria have also been undertaken. A problem which was encountered with a virus infection in our mosquito colony stimulated a series of studies into the action of some antiviral agents on polyhedrosis virus in Anopheles stephensi. Ultrastructural studies of treated and control mosquitoes are included in this report. Keywords Chemotherapy.