Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs, Treatment and Prophylaxis
Annual rept. 1 Sep 1986-31 Aug 1987
ASH STEVENS INC DETROIT MI
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The program is directed at the preparation of improved antileishmanial and antitrypanosomal drugs. During the past year 14 target compounds were submitted for testing against L. donovani, T. rhodesiense and T. cruzi. Two candidate antileishmanials are modified 8-aminoquinolines. Twelve compounds were directed primarily against T. cruzi., all modified Wellcome Research Laboratories structures. These included four 2,2-diaryldimethyl or dihydroaminomethylethylenes, one 2,2diarylaminomethyl-2-hydroxyethane, two 2, 2diarylamidoximinoethylenes, four 1,2,2-triaryldimethyl or dihydro aminomethylethylenes and one 1,1,2-triarylaminomethyl-2-hydroxyethane. Keywords Methylenes Ethylenes Ethanes.