Accession Number:

ADB120959

Title:

Design, Synthesis and Study of Biomimetic Catalysts.

Descriptive Note:

Final rept. 15 Mar 83-15 Sep 87; Annual rept. 16 Jun 86-15 Sep 87,

Corporate Author:

ALBERTA UNIV EDMONTON DEPT OF CHEMISTRY

Personal Author(s):

• Brown, Robert S.

Report Date:

1987-12-01

Pagination or Media Count:

20.0

Abstract:

Biomimetic catalysts modelled after the alkaline phosphatases and acid phosphatases were synthesized, and their catalysis of the hydrolysis of phosphate triesters was studied. The compounds fall into three classes those that bind one divalent M2-ion those that bind two M2 - ions and those that contain an imidazole with a pendant guanidinium ion. The syntheses of the compounds in the former two classes is described along with the summary of in vitro assays. the Zn2 and Co2-chelates of these are respectable catalysts for hydrolysis of triesters. The guanidinium imidazoles are ineffective catalysts. Keywords Biomimetic, Catalyst, Organophosphate ester, Alkaline phosphatase, Acid phosphatase, Chelates.

Descriptors:

• *CATALYSIS
• *CATALYSTS
• *ESTERS
• *HYDROLYSIS
• *ORGANOPHOSPHATES
• *SYNTHESIS(CHEMISTRY)
• ACID PHOSPHATASE
• ACIDS
• ALKALINITY
• ASSAYING
• CHELATE COMPOUNDS
• GUANIDINES
• IN VITRO ANALYSIS
• IONS
• PHOSPHATASES
• PHOSPHATES
• COBALT

Subject Categories:

• Organic Chemistry
• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE