Synthesis of Nucleoside Analogues with Potential Antiviral Activity Against Negative Strand RNA Virus Targets.
Annual rept. 1 Sep 86-31 Aug 87,
BIRMINGHAM UNIV (UNITED KINGDOM)
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The purpose of this work is to synthesis nucleoside analogues which are targeted against the replicase of negative-strand viruses. Two lines of investigation have been started i the synthesis of 5-vinyl substituted pyrimidine ribonucleosides and ii the synthesis of potential ribonucleoside 5 -triphosphate analogues. A series of compounds of type i have been synthesised and submitted for biological evaluation. One compound of type ii has been made and further work is in progress. Keywords Antiviral agents Chemical analogs SynthesisChemistry Chemotherapy.