Accession Number:

ADB119542

Title:

Synthesis of Nucleoside Analogues with Potential Antiviral Activity Against Negative Strand RNA Virus Targets.

Descriptive Note:

Annual rept. 1 Sep 86-31 Aug 87,

Corporate Author:

BIRMINGHAM UNIV (UNITED KINGDOM)

Personal Author(s):

Report Date:

1987-11-01

Pagination or Media Count:

39.0

Abstract:

The purpose of this work is to synthesis nucleoside analogues which are targeted against the replicase of negative-strand viruses. Two lines of investigation have been started i the synthesis of 5-vinyl substituted pyrimidine ribonucleosides and ii the synthesis of potential ribonucleoside 5 -triphosphate analogues. A series of compounds of type i have been synthesised and submitted for biological evaluation. One compound of type ii has been made and further work is in progress. Keywords Antiviral agents Chemical analogs SynthesisChemistry Chemotherapy.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE