Rare 2-Substituted Purine Nucleosides
Annual rept. 18 Oct 1986-17 Oct 1987
IOWA UNIV IOWA CITY
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This project is concerned with the synthesis of rare 2-substituted purine nucleosides with therapeutic potential against RNA viruses. In the second year of the contract, eleven rate 2-substituted purine nucleosides were synthesized, purified, fully characterized, and submitted to the Department of Antiviral Studies. Antiviral screening data have been received on a few of the compounds submitted and there are some very interesting and positive results. One compound 2-acetonylinosine, AVS-002159 has been found to have very high activity against the SF virus. Another compound 2-vinylinosine, AVS-002716 has been found to have broad spectrum activity against a number of RNA viruses. Two other compounds AVS-002883 and AVS-002884 have shown some activity against the RVF virus, and still another AVS-002352 has shown activity against the YF virus. Five publications have appeared in 1987 on this work. Keywords Rift Valley Fever virus Yellow fever virus Nucleoside, SynthesisChemistry.