Multiple Animal Studies for Medical Chemical Defense Program in Soldier/ Patient Decontamination and Drug Development on Task 84-4: Tissue Distribution of Arsenic in the Rabbit Following Subcutaneous Administration of Lewisite with or without British Anti-Lewisite Therapy
Final rept. 1 Dec 1984-1 Jul 1985
BATTELLE COLUMBUS DIV OH
Pagination or Media Count:
A task was performed to determine if multiple intramuscular injections of British Anti-Lewisite BAL or 2,3-dimercapto-1-propanol administered to rabbits at a non-toxic dosage afforded therapeutic benefits following a challenge dose of Lewisite L, with particular emphasis on determining if BAL mobilized arsenic As for accumulation in neural tissues. BAL significantly reduced concentrations of AS in blood, brain, spinal cord, lung, liver, testes, and kidneys. Arsenic accumulated in brain and spinal cord tissues in rabbits not receiving BAL therapy whereas, BAL therapy reduced As concentration in these tissues to near the vehicle control level. Keywords Lewisite L, CSM, Antidotes, Arsenic.
- Chemical, Biological and Radiological Warfare