Accession Number:

ADB113186

Title:

Preformulation and Formulation of Investigational New Drugs

Descriptive Note:

Annual progress rept. 10 Mar 1984-10 Feb 1985

Corporate Author:

IOWA UNIV IOWA CITY COLL OF PHARMACY

Personal Author(s):

• Lach, John L.
• Flanagan, Douglas R.
• Matheson, Lloyd E., Jr

Report Date:

1985-07-01

Pagination or Media Count:

163.0

Abstract:

This annual report contains preformulation and formulation studies on WR249,655.2CHI-6.2C1, WR238,605, WR171,669.HC1 Halofantrine HC1, WR249,943. 2C1 MMB-4.2CL, WR142,490.HC1 MEFLOQUINE CH1 and Pyridostigmine Bromide. These studies include stability studies on WR249,655.2CL and WR249,943.2C1 physicochemical characterization of WR238,605 investigation of solid-state properties of various lots of WR171,669.HCL and WR142,490.HCL initial development studies for a sustained release pyridostigmine bromide tablet. Keywords Oximes Antioxidents Antidotes.

Descriptors:

• *SYNTHESIS(CHEMISTRY)
• *DRUGS
• METHYL RADICALS
• ANTIDOTES
• BROMIDES
• ANTIOXIDANTS
• SOLID STATE ELECTRONICS
• HYDROXYL RADICALS
• PYRIDINES
• OXIMES
• CARBAMATES
• TABLETS(CHEMICAL)

Subject Categories:

• Pharmacology
• Industrial Chemistry and Chemical Processing

Distribution Statement:

APPROVED FOR PUBLIC RELEASE