Design and Synthesis of Candidate Prophylactic and Therapeutic Compounds for use in the Management of Organophosphorus Poisoning.
Final rept. 1 Sep 81-30 Sep 84,
ASH STEVENS INC DETROIT MI
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The program is directed at the design and synthesis of new compounds for use in the management of organophosphorus poisoning. In the past three years, 48 compounds were submitted 26 organophosphinates, one organophosphinothioate, 2 organophosphonates, 2 organophosphates, one oxophospholane, 7 carbamates, 2 sugar oximes, 2 aminoalkylselenic and selonic acids and five other organic compounds. Keywords Organophosphates Carbamates Prophylactics Therapeutics Antidotes.