Controlled-Release Personal Use Arthropod Repellent Formulation
Final rept. 24 Sep 1984-23 Sep 1985 on Phase 1
BIOTEK INC WOBURN MA
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BIOTEK, Inc. has developed an arthropod repellent formulation containing N,N,-diethyl-m-toluamide Deet for topical application to exposed skin which will provide protection for a duration of 12 hours. This has been achieved by formulating the active ingredient, Deet, with a proprietary blend of silica gel, a lotion base, and alcohol. The formulation is non-toxic, is cosmetically acceptable, is more compatible with military materials than the current in-use formulation, and complies with EPA specifications. In vitro testing of our formulation in a Reifenrath permeationevaporation cell using weanling pig skin shows an evaporation rate greater than the minimum effective evaporation rate described by the Request for Proposal for a period of 22 hours. Under standard clinical test conditions of moderate temperature and humidity, the formulation provided 100 protection against Aedes aegypti mosquitoes for at least 12 hours, at an applied formulation dose of 2 mg per square centimeter. It is expected that protection may be maintained beyond 12 hours since complete protection was evident at 12 hours when testing was concluded.
- Hygiene and Sanitation