Accession Number:

ADB090890

Title:

Studies on the Biodisposition of Organophosphates in Mice

Descriptive Note:

Annual summary rept. 1 Aug 1982-31 Jul 1983

Corporate Author:

MEDICAL COLL OF VIRGINIA RICHMOND DEPTOF PHARMACOLOGY AND TOXICOLOGY

Personal Author(s):

Report Date:

1983-08-01

Pagination or Media Count:

39.0

Abstract:

The biodisposition of radioactivity was studied in mice following the i.v. administration of 3H-DFP 1 mgkg. EH-DFP penetrated tissues rapidly so that within 1 min of drug administration, maximal levels of radioactivity were found in brain, lung, heart and kidney. The peak levels of radioactivity in liver, diaphragm and fat occurred at 5 min. Tissue levels remained elevated for approximately 8 hr. The rank order of tissue concentrations during this period of time was liver plasma kidney heart diaphragm fat. Radioactivity declined appreciably by 3 days, and after 7 days the highest concentrations were found in liver and lung with somewhat lower concentrations in kidney. It may be that lung and liver are potential storage depots under certain circumstances. Radioactivity was readily extracted from brain homogenates 85 removed by ethyl acetate 1 min after administration, but the amount that was nonextractable increased with time. A relatively small portion 13-24 of the radioactivity was extractable from the other tissues at the early time points, but even these small percentages decreased with time. It appears that enzyme aging occurs slowly or to a limited degree in mice, but further experimentation will be necessary to establish the extent to which it occurs. Originator-supplied keywords include diisopropylfluorophosphate, tissue disposition, and anticholinesterase activity.

Subject Categories:

  • Radiobiology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE