Drug Evaluation in the Plasmodium falciparum - Aotus Model
Annual rept. 1 Jan-15 Jul 1984, Final rept. 1 Jul 1976-15 Jul 1984
GORGAS MEMORIAL LAB APO MIAMI 34002
Pagination or Media Count:
Three strains of Plasmodium falciparum, Uganda Palo Alto, Vietnam Smith, and Vietnam Oak Knoll, and one strain New Guinea Chesson of P. vivax were adapted to Panamanian Aotus Trivirgatus. These models were used to evaluate the blood schizonticidal and curative activity of experimental antimalarial drugs. WR 228258, a 4-aminoquinoline, cured infections of P. falciparum as follows a chloroquine-resistant strain by a dose of 2.0 mg base per kg x 3 days, and a chloroquine-sensitive strain by a dose of 1.0 mg base per kg x 3 days. Two 8-aminoquinolines, WR 225448 at a dose of 4.0 mg bse per kg x 3 days and WR 242511, at a dose of 1.0 mg base per kg x 3 days, cured blood induced P. vivax infections. An acridine, WR 243251, cured infections of a chloroquine-sensitive strain of P. falciparum at a dose of 1.0 mg base per kg x 3 days and infections of a chloroquine-resistant strain at a dose of 4.0 mg base per kg x 3 days. Blood induced infections of P. falciparum or P. vivax were cured by WR 250547 acridinol by a dose of 1.0 mg base per kg x 3 days.