Prevention of Influenza and Other Respiratory Diseases
Annual progress rept. 1 Jul 1977-31 Jan 1978
COLORADO UNIV MEDICAL CENTER DENVER
Pagination or Media Count:
Antibody studies on 23 unvaccinated and 30 vaccinated persons with A Texas77 influenza showed that almost all had been infected previously with H3N2 strains. HI titers were highest against the earliest strain and diminished progressively with more recent strains. They were lowest with ADenver77, the epidemic strain. Neuraminidase inhibiting NI antibody titers were low in the acute sera of unvaccinated persons, but 15 of 33 vaccinated persons had titers of or 16. The NI titer levels were of less value in predicting protection against influenza illness that HI antibody levels against the epidemic strain. The most useful tests for serodiagnosis were HI tests using the epidemic strain and complement-fixation tests. NI tests and HI tests with earlier H3N2 strains were less sensitive, particularly in vaccinated persons. The Lowry Air Force Base population, which had received AVictoria75 vaccine in November, 1977 had only a scattering of cases of influenza even though influenza A, mainly A victoria75, was widespread in the Denver area in December, 1977 and January, 1978. HI tests for antibody for H1N1 strains showed that persons under 23 years of age lacked antibody for AFM147, AAA57 or the new epidemic strain AUSSR 9077. A large proportion of persons between 23 and 32 and a smaller proportion of older persons had antibody. Titers were considerably higher for AFM147 than for AAA57 or AUSSR9077.
- Medicine and Medical Research