Immunopathology of Malaria and Other Hemosporidian Infections.
Annual progress rept. no. 3, 1 Oct 67-30 Sep 68,
MICHIGAN STATE UNIV EAST LANSING DEPT OF MICROBIOLOGY AND PUBLIC HEALTH
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The solution sought in this research project is the discovery of the mediators of disease, anemia, splenomegaly, petechial hemorrhage and nephritis in human malaria. The approach is based on the concept that disease is mediated by in vivo immunologic reactions rather than by toxic substances elaborated by the parasites. This concept has received general acceptance in cases of most of the infectious diseases caused by fungi, bacteria, rickettsiae or the viruses. However, in the cases of malaria, the immunologic mechanisms are obscure. Thus in this project, research must be directed at discovering and defining the immune mechanisms, and then to seek for a causal relationship between the allergic state andor the antibodies of immunity and the diseases associated with malaria. Keywords Immunopathology, Malaria, Hemosporidian infections, Medical research, UA Reports. JG
- Medicine and Medical Research