A Study of Tolerance and Safety of a Combination of Anti-Malarial Drugs in Young Adult Males.
Final rept. 9 Mar 70-31 May 72,
FLORIDA UNIV GAINESVILLE COLL OF MEDICINE
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The purpose of this study was to determine the safety for extended use in humans of 4,4diformamidodiphenylsulfone DFD an antimalarial drug proven effective if given once a week with chloroquine-primaquine. Currently, the usual treatment for malaria utilizes another sulfone, diaminodiphenylsulfone DDS in combination with chloroquine-primaquine. However, to maintain effectiveness, DDS must be given daily. DFD, requiring only weekly administration, offers an obvious advantage. It is concluded that long-term up to 52 weeks administration of DFD to male prison volunteers had no serious untoward effects. There is no build-up of the drug as a result of a single weekly oral dose of 800 mg.