Accession Number:

ADA955147

Title:

The Effect of Hypoxia on the Pulmonary Microcirculation.

Descriptive Note:

Rept. no. 1 (Annual) 1 Oct 67-30 sep 68,

Corporate Author:

COLORADO UNIV AT DENVER MEDICAL CENTER

Personal Author(s):

Report Date:

1968-09-30

Pagination or Media Count:

15.0

Abstract:

A technique designed to permit direct microscopic observation via a transparent window implanted in the chest wall of dogs of the pulmonary capillaries in vivo has been developed. Cine- and photomicrographic techniques have been developed to permit high speed, high resolution study of the pulmonary microcirculation. These systems have been designed to provide information related to the following 1 The velocity of the erythrocytes as they cross the alveolar capillary net to determine contact time between oxygen and hemoglobin, 2 the orientation of the erythrocytes in the capillaries to determine the intracapillary diffusion distance of molecular oxygen 3 the site of action of the hypoxic vasopressor response, and 4 the quantitation of the oxyhemoglobin gradient along the microcirculation to determine a the boundaries of the oxygen uptake process, b the shape of the uptake curve, and c how the curve and boundaries are affected by stress, e.g. hypoxemia or exercise.

Subject Categories:

  • Anatomy and Physiology
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE