Attempts to Produce a Vaccine against Schistosoma mansoni Infection in Mice.
Final rept. May 73-Apr 74,
UNIVERSIDADE FEDERAL DE MINAS GERAIS BELO HORIZONTE (BRAZIL) INSTITUTO DE CIENCIAS BIOLOGICAS
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An attempt was made to produce a living vaccine using nicarbazin - that stop egg laying - in a long therapeutic schedule. Despite the immunity displayed to reinfection, the goal to get sterile live worms was not successful. It was observed that in Cebus monkeys reinfection with Schistosoma mansoni occurs after successful chemotherapy. Schistosomules recovered from the lung of mice 4 days after exposure to 3,000 cercariae were injected intravenously 50 larvae per animal. The percentage of worm recovery was 64.8. It has been demonstrated that cercarial bodies Schistosoma mansoni, bodies without secretion and coat and tail-loss bodies are infective for mice by the subcutaneous, intraperitoneal and intravenous routes. It was found that some tetrahydro- and pyrazinoquinolines are active against early developing schistosomes in the peritoneal cavity of mice. The results obtained with a new technique for screening prophylactic agents in schistosomiasis was presented.
- Medicine and Medical Research