Accession Number:

ADA954876

Title:

Development and Investigation of a Cell Culture Model of Morphine Addiction.

Descriptive Note:

Final rept.,

Corporate Author:

MINNESOTA UNIV MINNEAPOLIS

Personal Author(s):

Report Date:

1974-09-15

Pagination or Media Count:

19.0

Abstract:

Initial experiments were directed to finding a morphine effect on growth of Novikoff Hepatoma cells. Data obtained provided the information that between 5x10 to the minus 4 and 10 to the minus 3m morphine sulfate were growth inhibitory. Further experiments did not reproduce initial success. We then switched to a fibroblastic cell type--mouse L cells. Initial results were encouraging, indicating that some dependence of L cells on the presence of morphine developed. Again repeated experiments failed to show this phenomenon.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE