The Treatment of Shock Based Upon Physiological Principles and Impedence Method for Measuring Cardiac Output in Shock
Annual rept. 1 Jan-31 Dec 1966
MINNESOTA UNIV MINNEAPOLIS
Pagination or Media Count:
Hemorrhagic, endotoxin and cardiogenic shock has been characterized experimentally by reduction in tissue perfusion and the development of a significant degree of peripheral vasoconstriction. In each case, therapy directed at restoration of an effective circulating blood volume and reduction of a peripheral vasoconstrictor response is associated with a significant improvement in survival. Preliminary clinical studies in 50 patients are consistent with the experimental findings in dogs. Likewise, similar therapeutic techniques in man have provided additional evidence that reduction of the peripheral vasoconstrictive response is associated with improvement in survival. Experimentally, tolerance has been produced to both epinephrine and endotoxin. Tolerant dogs do not exhibit the same magnitude of vasoconstrictive response to usually lethal septic or cardiogenic shock. Survival rate in shock appears to be correlated with the reduction of the peripheral vasoconstrictive response in the face of an effective circulating blood volume.
- Medicine and Medical Research