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The Treatment of Shock Based upon Physiological Principles and Impedence Method for Measuring Cardiac Output in Shock.

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Annual progress rept. 1 Jan-31 Dec 64,

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In the shock syndrome, various initial stresses lead to a common, hemodynamic pathway of severely reduced tissue perfusion with hypoxemia and acidosis. The goal in shock treatment is to restore a state of circulatory balance in which the volume of blood perfusing tissue, especially certain vital viscera, carries with it enough oxygen to meet the tissue metabolic requirement for oxygen MRO2. Metabolic acidosis is a consequence of hypoxemia and is best corrected by restoring adequate tissue oxygenation. Cardiac output is reduced by interfering directly with myocardial contractility by altering coronary artery perfusion pressure and by altering the distribution of oxygenated blood to e myocardium. For the past year, we have focused our attention to the elaboration and dissection of some of the cardiac mechanisms operating in shock. Investigations of the treatment of shock based upon physiological principles have proceeded in three phases Hemorrhagic Shock 2 Gram-negative bacterial endotoxinemic shock and Cardiogenic Shock. Models of each have been developed and standardized in the dog, and treatment methods have been studied with respect to circulatory hemodynamics, biochemical changes and survival value. Originator supplied keywords include Shock Cardiac output Blood volume Peripheral resistance.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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