Immunological Studies on Heroin Addiction.
Annual rept. Aug 73-Jun 74,
PUBLIC HEALTH RESEARCH INST OF THE CITY OF NEW YORK INC
Pagination or Media Count:
Hemagglutination-inhibition HI procedures for the detection and measurement of several abused drugs have been further developed and evaluated. Tests for morphine and for methadone have been applied to more than 30,000 urine specimens. The HI test for barbiturates is operational but requires further work toward increased sensitivity. AN HI test for ecgonine has been shown to detect this drug and benzoylecgonine in urines containing 30 ngml or more of these drugs but suitable antisera have proven to be difficult to prepare. Preliminary results suggest the feasibility of detecting LSD by HI. The results of further studies on sporadic recurrent excretion of morphine are reported. Also presented are data which illustrate individual-specific responses to drug protein conjugates. Progress toward the use of immunoadsorbants for concentration and purification of drugs in biological fluids is also reported.
- Medicine and Medical Research