Accession Number:

ADA634964

Title:

Effects of Naloxone on Stress and Performance

Descriptive Note:

Doctoral thesis

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s):

Report Date:

1987-11-10

Pagination or Media Count:

157.0

Abstract:

Studies suggest that exposure to unpredictable stressors results in performance deficits following stressor termination. Stressor exposure may also be accompanied by activation of the endogenous opioid system which may play a role in affective responding to stressors. It is possible that opioid effects are related to these aftereffects of stress because opioids cause effects that are similar to aftereffects. The major hypothesis of this study was that naloxone, an opioid antagonist, would ameliorate aftereffects due to exposure to uncontrollable noise. It was also hypothesized that naloxone would increase the reported aversiveness of the stressor, but would have no effect on simple performance during stressor exposure.

Subject Categories:

  • Medicine and Medical Research
  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE