Accession Number:

ADA634939

Title:

Canine Antithrombin-III: Some Biochemical and Biologic Properties

Descriptive Note:

Doctoral thesis

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s):

Report Date:

1987-06-02

Pagination or Media Count:

93.0

Abstract:

Coagulopathies have been reported to occur after many forms of stress and trauma. These thrombohemorrhagic responses are likely consequent to disturbances of the delicate interplay of the hemostatic compartments vasculature, platelets, and plasma proteins, resulting in the systemic activation of the clotting-fibrinolytic and other systems with eventual depletion of critical hemostatic components. This syndrome of generalized intravascular proteolysis or disseminated intravascular coagulation DIC, an intermediary mechanism of disease, is usually but not always associated with well-defined clinical entities. It can manifest as a wide clinical spectrum. For example, if the intravascular clotting process is dominant and secondary fibrinogenolysis minimal, DIC may be expressed primarily as diffuse thromboses, as in malignancy. Alternatively, if the secondary fibrinolysis which occurs with DIC is dominant, and the drive toward procoagulant activity minimal, the clinical manifestations will be hemorrhage, by far the more common expression of DIC 1-4. Patients often demonstrate combinations of these two clinical manifestations. Thus, DIC represents a wide spectrum of clinical findings with patients presenting anywhere in the continuum between diffuse thromboses andor hemorrhage 1,4,5.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE