Evaluation of Gastric Function in Primates Following the Administration of Agents Which Act at the Kappa Receptor
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
Pagination or Media Count:
The physiological effects of kappa agonists on gastric function have not been fully elucidated. In the present studies, the effect of kappa receptor agonists dynorphin1-13, U50,488H and ketocyclazocine, a putative antagonist of the kappa receptor MR1452 MS, and a nonspecific opiate antagonist Naloxone , on gastric emptying and secretion were evaluated alone and in combination. A marker dilution technique was used to measure, concurrently, gastric fractional emptying rate and secretion in conscious, chair-adapted rhesus monkeys during a fasting period and following the intragastric administration of an 80 ml water load pH 7.4, 37 C. All values listed as significant had a p value of less than 0.05. The opioid agonists utilized in these studies inhibited gastric emptying. Unlike agonists that are active at mu morphine and delta enkephalins receptors, selective kappa agonists dynorphin-1-13 U50,488H did not alter acid secretion, while the kappamu agonist, ketocyclazocine, significantly decreased it.
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