Early Phase Endotoxin Tolerance: A Study of the Cellular Mechanisms which Underlie a State of Acquired Refractoriness to Endotoxin-induced Toxic Manifestations
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
Pagination or Media Count:
Endotoxin, the lipopolysaccaride LPS cell wall component which is derived from Gram negative bacteria, has been shown to induce a number of toxic manifestations which mimic those seen during systemic Gram negative infection. Hyporesponsiveness to the toxic effects of LPS can be induced for a transient period by per-exposure of a normally responsive individual to a sublethal dose of LPS. This acquired state of refractoriness to the toxic effects of LPS has been defined as early endotoxin tolerance. Little is known about the cellular mechanisms that underlie this phenomenon. In this study, an early tolerance system was established by the injection of mice with 25 micrograms of Escherichia coli K235 LPS. Maximal hyporesponsiveness in response to a challenge injection was observed 3 to 4 days after the initial injection, and normal responsiveness returned by 8 days after the initial exposure to LPS.
- Medicine and Medical Research