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Accession Number:
ADA628365
Title:
Delayed Partial Liquid Ventilation Shows no Efficacy in the Treatment of Smoke Inhalation Injury in Swine
Descriptive Note:
Journal article
Corporate Author:
ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
Report Date:
2001-06-01
Pagination or Media Count:
11.0
Abstract:
In an earlier neonatal porcine model of smoke inhalation injury SII, immediate postinjury application of partial liquid ventilation PLV had dramatic beneficial effects on lung compliance, oxygenation, and survival over a 24-h period. To explore the efficacy of PLV following SII, we treated animals at 2 and 6 h after SII and followed them for 72 h. Pigs weighing 8 12 kg were sedated and pharmacologically paralyzed, given a SII, and placed on volume-cycled, pressure-limited ventilation. Animals were randomized to three groups group I SII, no PLV, n 8, group II SII, PLV at 2h, n 6, and group III SII, PLV at 6 h, n 7. Ventilatory parameters and arterial blood gasses were obtained at scheduled intervals. The PLV animals groups II and III followed a worse course than group I no PLV PLV groups had higher peak and mean airway pressures, oxygenation index, and rate-pressure product a barotrauma index and lower lung compliance and arterial partial pressure of oxygen-to-inspired oxygen fraction ratio all P less than 0.05. PLV conferred no survival advantage. The reported beneficial effects of PLV with other models of acute lung injury do not appear to extend to the treatment of SII when PLV is instituted in a delayed manner. This study was not able to validate the previously reported beneficial effects of PLV in SII and actually found deleterious effects, perhaps reflecting the predominance of airway over alveolar disease in SIL.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
