Accession Number:

ADA627935

Title:

A New Therapeutic Paradigm for Breast Cancer Exploiting Low Dose Estrogen-Induced Apoptosis

Descriptive Note:

Annual rept. 1 Sep 2011-18 May 2012

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

2012-06-01

Pagination or Media Count:

322.0

Abstract:

The purpose of the CoE is to discover the molecular mechanisms and the modulation of estrogen-induced apoptosis. The laboratory research project is focused on genomics nad proteomics with a current focus on molecular interrogation to decipher mechanisms that may be applied to aid patient treatment. In parallel, but not supported by the CoE, is a pilot clinical study of estrogen-induced apoptosis in patients with metastatic breast cancer, that have had repeated cycles of successful antihormone therapy, but have subsequently failed and relapsed.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE