Inhibiting Inosine Hydrolase and Alanine Racemase to Enhance the Germination of Bacillus anthracis Sterne Spores: Potential Spore Decontamination Strategies
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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Interest in context of novel decontamination strategies Increase of the germination rate induce By inhibiting Air and lunH separately. By inhibiting the both concommitantly iunH mutant spores positively affected by the block of Air. Better understanding and manipulating spore germination. Induction of the transition from highly resistant ungerminated spores to much more susceptible and less virulent germinated spores. Strengthens the early work published in 2013 and 2014 showing that spore germination rates are augmented potentially improving decontamination strategies.
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare