Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI
Annual rept. 30 Sep 2014-29 Sep 2015
ALABAMA UNIV IN BIRMINGHAM
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This study will evaluate Constraint-Induced Movement CI therapy for promoting motor recovery in veterans and civilians with traumatic brain injury TBI. This form of physical rehabilitation has been shown to substantially improve motor function after brain injury not due to trauma and to provoke a widespread neuroplastic response in the brain. This study N 80is a single blind, randomized controlled trial that compares CI therapy for improving useof the more-affected arm in adults with TBI to a holistic fitness program named Lakeshore Enriched Fitness Training LEFT. In addition to assessing changes from pre-treatment in more-affected arm motor function at post-treatment and 1-year afterwards, changes will be examined in white matter, grey matter, and functional brain activity. Products at the end of the first year of this blinded study are a manual of procedures and a method for generating synthetic neuroimaging data for the purpose of evaluating the sensitivity of the techniques proposed for quantifying changes in grey matter.
- Anatomy and Physiology
- Medicine and Medical Research