Accession Number:

ADA626551

Title:

Study of Tranexamic Acid During Air Medical Prehospital Transport Trial (STAAMP trial)

Descriptive Note:

Annual rept. 30 Sep 2014-29 Sep 2015

Corporate Author:

PITTSBURGH UNIV PA

Report Date:

2015-10-01

Pagination or Media Count:

6.0

Abstract:

The enrollment for this study began at the University of Pittsburgh on 11-JUN-2015. External sites are in the process of submitting their initial IRB application and the community consultation plan is either in the development stage or recently initiated. Pittsburgh Coordinating Center is awaiting IRB approval regarding changes to the protocol language. The primary hypothesis is that the prehospital infusion of tranexamic acid in patients at risk for bleeding will reduce the incidence of 30 day mortality. The secondary hypotheses include that prehospital tranexamic acid will reduce the incidence of hyperfibrinolysis, acute lung injury, multiple organ failure, nosocomial infection, mortality, early seizures, pulmonary embolism and early resuscitation needs, reduce or prevent the early coagulopathy as demonstrated by improving presenting INR and rapid thromboelastography parameters, reduce the early inflammatory response, plasmin levels, leukocyte, platelet and complement activation, and determine the optimal dosing of tranexamic acid post-injury.

Subject Categories:

  • Medicine and Medical Research
  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE