Accession Number:

ADA626490

Title:

Clinical Validation of a miRNA Blood Test to Identify High-Risk Individuals Eligible for Low-Dose Computed Tomography Screening for Lung Cancer Early Detection

Descriptive Note:

Annual rept. 30 Sep 2014-29 Sep 2015

Corporate Author:

EUROPEAN INST OF ONCOLOGY MILAN (ITALY)

Personal Author(s):

Report Date:

2015-10-01

Pagination or Media Count:

11.0

Abstract:

The overall objective of this project is to validate whether a lung cancer diagnostic blood test that is based on the detection of a signature of 34 circulating miRNAs miR-Test can be used to identify individuals who require further investigation by LDCT screening. The project requires the use of serum samples obtained from at-risk subjects heavy smokers with defined characteristics undergoing LDCT screening. Such samples can be classified into two risk classes Bach-high, and Bach-low, as determined by a risk model developed at IEO. Under separate funding, samples from Bach-high subjects are being analyzed using the miR-Test. The DoD-funded project aims to improve the clinical applicability of the miR-Test blood test by analyzing 1000 serum samples of Bach-low individuals. A parallel study of 1000 individuals undergoing LDCT screening at the Mount Sinai School of Medicine MSSM in New York will provide validation of the miR-Test in an independent, non-Italian cohort of at-risk individuals to assess its applicability internationally. At 12 months, work is in the early phases of profiling the miRNA signatures of the collected serum samples.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE