Accession Number:

ADA626427

Title:

Mechanobiocatalysis: Modulating Enzymatic Activity with Mechanical Force

Descriptive Note:

Final rept. 15 Sep 2011-14 Sep 2014

Corporate Author:

TEXAS UNIV AT AUSTIN

Personal Author(s):

Report Date:

2015-09-28

Pagination or Media Count:

8.0

Abstract:

A primary objective of this project is to use externally-applied mechanical forces to control the intrinsic activities displayed by enzymes and other materials. It was demonstrated that the application of forces to enzymes properly outfitted with polymers resulted in distortions at the active sites of the corresponding enzymes. For example, polymer-protein composites were found to display photophysical properties that were dependent on the applied force. Recent efforts have focused on new classes of polymeric materials that effectively resist mechanical degradation.

Subject Categories:

  • Biochemistry
  • Polymer Chemistry
  • Mechanics
  • Solid State Physics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE