Imaging Prostatic Lipids to Distinguish Aggressive Prostate Cancer
Annual rept. 8 Aug 2014-7 Aug 2015
OREGON HEALTH AND SCIENCES UNIV PORTLAND
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In this application, we propose to build upon our current work to determine the association between fatty acid synthase FAS overexpression and intraprostatic fat as measured by in-vivo imaging using proton magnetic resonance spectroscopy imaging in the prediction of prostate disease aggressiveness. Mechanisms linking fatty acid synthase overexpression, lipid accumulation, lipid oxidation, and tumor aggressiveness will be explored using metabolomics. Employing a cross-sectional design we will recruit 50 men with low-grade and 50 men with high grade prostate cancer post-diagnosis as determined prior to prostatectomy. Each patient will complete one proton magnetic resonance spectroscopy imaging session and provide access to his prostatectomy tissue. Among men diagnosed with low grade proposed as more indolent and high grade proposed as more aggressive prostate cancer as determined by Gleason scoring we propose to 1 Determine the correlation between FAS expression in prostatectomy samples and the amount of intraprostatic lipid using 1H magnetic resonance spectroscopic imaging proton MRSI with an endorectal coil. 2 Identify the association between FAS expression and FAS activity in prostatectomy samples, intraprostatic lipid as measured by MRSI and prostate tumor aggressiveness. 3 To quantify key metabolic intermediates involved in lipid metabolism, mitochondrial function, inflammation, and apoptosis in the prostatectomy samples.
- Medicine and Medical Research