Bone Repair and Military Readiness
Final rept. 21 May 2014-18 Jul 2015
MISSOURI UNIV-KANSAS CITY
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Even though commercial bone cements have not significantly changed in the past 50 years and have been used throughout the world, there are significant drawbacks with the current systems. We have developed a silorane based resin superior to polymethyl methacrylate PMMA with many improved properties such as significantly less polymerization stress without an associated reduction in mechanical properties. The specific aims for this project are Specific Aim 1 Develop a silorane bone cement suitable for in vivo studies and to optimize the formulation of the chemically and mixed cured cement prototypes. Specific Aim 2 Determine the biocompatibility properties and wear debris generation of silorane bone cement prototype. Specific Aim 3 Determine the biological response to silorane bone cement prototype in animal models. By addressing the shortcomings of current PMMA bone cement, the development of the novel silorane bone cement will result in a paradigm shift in orthopedic biomaterials.
- Anatomy and Physiology
- Medicine and Medical Research