Accession Number:

ADA626271

Title:

Biocompatible Surface Chemistry Manipulation of Gold Nanorods Preserves Optical Properties for Bio-Imaging Applications

Descriptive Note:

Journal article

Corporate Author:

AIR FORCE RESEARCH LAB WRIGHT PATTERSON AFB OH HUMAN PERFORMANCE WING (711TH) HUMAN EFFECTIVENESS DIR/ BIOEFFECTS DIVISION

Report Date:

2015-12-18

Pagination or Media Count:

19.0

Abstract:

Due to their anisotropic shape, gold nanorods GNRs possess a number of advantages for biosystem use including, enhanced surface area and tunable optical properties within the near-infrared NIR region. However, cetyl trimethylammonium bromide-related cytotoxicity, overall poor cellular uptake following surface chemistry modifications, and loss of NIR optical properties due to material intracellular aggregation in combination remain as obstacles for nanobased biomedical GNR applications. In this article, we report that tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide MTAB GNRs MTAB-TA show no significant decrease in either in vitro cell viability or stress activation after exposures to A549 human alveolar epithelial cells. In addition, MTAB-TA GNRs demonstrate a substantial level of cellular uptake while displaying a unique intracellular clustering pattern. This clustering pattern significantly reduces intracellular aggregation, preserving the GNRs NIR optical roperties, vital for biomedical imaging applications. These results demonstrate how surface chemistry modifications enhance biocompatibility, allow for higher rate of internalization with low intracellular aggregation of MTAB-TA GNRs, and identify them as prime candidates for use in nanobased bio-imaging applications.

Subject Categories:

  • Physical Chemistry
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE