Accession Number:

ADA626217

Title:

Self-Expanding, Tough Biodegradable Elastomers for Wound Stasis

Descriptive Note:

Final rept. 1 Jul 2010-31 Mar 2014

Corporate Author:

ARSENAL MEDICAL INC WATERTOWN MA

Personal Author(s):

• Sharma, Upma

Report Date:

2015-08-06

Pagination or Media Count:

30.0

Abstract:

Noncompressible abdominal bleeding is a significant cause of preventable death on the battlefield and in the civilian setting, with no effective therapies available at point of injury. We previously reported that a self-expanding polyurethane foam significantly improved survival in a lethal hepatoportal injury model of massive venous hemorrhage. In this study, we hypothesized that foam treatment could improve survival in a lethal iliac artery injury model in noncoagulopathic swine.

Descriptors:

• *ABDOMEN
• *HEMORRHAGIC SHOCK
• *POLYURETHANE RESINS
• *WOUNDS AND INJURIES
• ARTERIES
• BATTLEFIELDS
• BIODETERIORATION
• BLOOD COAGULATION
• CARDIOVASCULAR SYSTEM
• CIVILIAN PERSONNEL
• CLINICAL MEDICINE
• ELASTOMERS
• EXPANDED PLASTICS
• LETHALITY
• RESUSCITATION
• SURGERY
• SWINE
• THERAPY
• TRAUMA

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research
• Plastics
• Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE