St. John's Wort for Major Depressive Disorder: A Systematic Review
RAND NATIONAL DEFENSE RESEARCH INST SANTA MONICA CA
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This systematic review synthesized evidence of St. John s wort SJW for the treatment of major depressive disorder MDD PROSPERO record CRD42015016406. In November 2014, we searched nine electronic databases, as well as bibliographies of existing systematic reviews, to identify randomized controlled trials RCTs testing the efficacy and safety of SJW to treat adults with MDD. Two independent reviewers screened publications using predetermined eligibility criteria, abstracted study-level information, and assessed the quality of included studies. Outcomes of interest included changes in depressive symptomatology, quality of life, and adverse effects. Efficacy meta-analyses used the Hartung- Knapp-Sidik-Jonkman method for random-effects models. Quality of evidence was assessed using the GRADE approach.
- Medicine and Medical Research