Omega-3 Fatty Acids for Major Depressive Disorder: A Systematic Review
RAND NATIONAL DEFENSE RESEARCH INST SANTA MONICA CA
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Major depressive disorder MDD is a prevalent condition that accounts for considerable suffering and lost productivity. Epidemiological evidence supports a potential role for dietary andor supplemental omega-3 n-3 fatty acids in the management of depression. We conducted a systematic review of randomized controlled trials RCTs that assessed the efficacy and safety of n-3 fatty acids for treating depression. We searched the electronic databases PubMed, PsycINFO, CINAHL, Embase, and AMED and screened recent existing reviews to identify English-language reports of randomized placebo-controlled or head-to-head trials testing the efficacy and safety of n-3 fatty acids as a monotherapy or adjunctive therapy to treat adults with MDD. Standard systematic review methods were used to screen the literature against a predetermined set of inclusion and exclusion criteria, abstract the study-level details and outcomes of interest, and assess the methodological quality of the studies. Effectiveness outcomes were pooled using the Hartung-Knapp-Sidik- Jonkman method for random-effects models. The quality of evidence for each conclusion was assessed using the GRADE approach.
- Medicine and Medical Research