Collaborative Core Research Program for Chemical-Biological Warfare Defense
Interim rept. Oct 2012-Oct 2014
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE WRIGHT-PATTERSON AFB OH
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Classical chemical nerve agents CNAs and numerous emerging chemical threats ECTs collectively referred to as chemical warfare agents CWAs share acetylcholinesterase AChE inactivation as a common target for their respective modes of action. To date, there is no known countermeasure with therapeutic efficacy for rescuing enzyme activity against a broad-spectrum of CWAs. Therefore, the major thrust of the work being performed by the Biological Modeling Group BMG at AFRL and its collaborators at the University of Cincinnatis Metabolic Diseases Institute UC-MDI and the Battelle Memorial Institutes Biomedical Research Center BBRC is focused on developing novel, broad spectrum countermeasures involving small molecule allosteric modulators for AChE activity. The research team hypothesizes that by utilizing allosteric modulation of the enzyme activity, treatment before or shortly after CWA exposure would protect the enzyme from inhibition.
- Chemical, Biological and Radiological Warfare