Meningococcal Polysaccharide Vaccine Failure in a Patient with C7 Deficiency and a Decreased Anticapsular Antibody Response
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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This is a case report of a military service member who received the meningococcal vaccine but died of the disease 15 months later. He had terminal complement component deficiency TCCD, and his anti-capsular antibody levels were inadequate. This case highlights the fact that some individuals with TCCD have an impaired or short-lived response to vaccination with meningococcal capsular polysaccharide, and it underscores the appropriateness of an initial two-dose series.