Investigation the Regulation and Potential Role of Nonhypoic Hypoxia-Inducible Factor 1 (HIF-1) in Aromatase Inhibitor-Resistant Breast Cancer
Annual summary rept. 15 Sep 2013 - 14 Sep 2014
MARYLAND UNIV BALTIMORE
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During the 2013-2014 period of the grade evidence is provided that HER2 and HIF-1alpha expression are temporally correlated in vivo in letrozole-treated tumor xenografts. In addition, further evidence is provided that nonhypoxic HIF-1 is involved in regulating cancer stem cell characteristics in letrozole-resistant breast cancer cells, as specific inhibition of HIF-1alpha by EZN-2968 decreased cancer stem cell characteristics i.e., microtentacle expression. However, HIF-1alpha does not seem to be associated with the vimentin promoter in LTLTCa cells, though it regulates its expression. Which suggests that HIF-1alpha may regulate this vimentin through an intermediary protein.
- Medicine and Medical Research