The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy
Annual rept. 8 Sep 2014 - 7 Sep 2015
WAKE FOREST UNIV WINSTON-SALEM NC SCHOOL OF HEALTH SCIENCES
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The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in regulation of tumor dormancy. Aim1 will identify and explore how DTCs stay dormant for long periods of time. We postulate that DTCs drive the bone marrow niche into dormancy through the GAS6 pathway. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. As a major accomplishment of this study during this period is that the PI, Dr. Yusuke Shiozawa, accepted a position as an Assistant Professor at Wake Forest School of Medicine as of 030115. The PI obtained the necessary institutional approvals IACUC, IRB, IBC and submitted the grant transfer request 06112015 to gain approval from the Department of Defense for a transfer of the award from the University of Michigan to Wake Forest School of Medicine. As a result, the progress of this award was suspended at Wake Forest School of Medicine during this period of time. Once the PI obtains the grant transfer approval from the Department of Defense, he will initiate the proposed research as soon as possible.
- Anatomy and Physiology